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Clinical Trials

Wherever possible we like to include feedback from women who have experienced breast cancer and their families. Sometimes their feedback will be inconsistent with current medical practice. Where this is the case, we provide a link to the relevant information on the Breasthealthlink website, so you can access the current medical view supported by leading Cancer organisations. Ed.

I was diagnosed with breast cancer in November 12. My first reaction to this was shock and disbelief as there was no previous history in my family.

Nancy - Aged 42

My name is Nancy. I am 42, married to a wonderful and supportive husband with two beautiful sons aged 10 and 12. I was diagnosed with breast cancer in November 12. My first reaction to this was shock and disbelief as there was no previous history in my family. I later learnt most breast cancers detected are not hereditary.

My treatment options were to have either a lumpectomy or mastectomy and axillary dissection, possibly followed by radiation therapy, chemotherapy and/or hormonal treatment depending on the outcome. My greatest fear was having the axilla dissected and the possible side effects of lymphoedema. I was resolved to having surgery to the breast but felt I needed more information about lymph node removal. This may appear a minor issue compared to having a life threatening disease but I am right-handed and my right arm would be affected.

I found a surgical oncologist who performs sentinel node biopsy, a procedure that identifies and removes the first lymph node to which the breast cancer cells might spread. The surgeon provided lots of information to read about sentinel node biopsy. I decided to proceed with it. Unfortunately my sentinel node contained some cancer cells and the recommended treatment was axillary dissection. I still felt uncomfortable with this and found there was another option for me, to enter a clinical trial being conducted at Peter MacCallum Cancer Institute. This trial was part of an international study by the American College of Surgeons Oncology Group - a randomised trial of axillary node dissection in women with a certain clinical breast cancer who have a positive sentinel node. I was a possible candidate.

My husband and I discussed the options. One was to have an axillary dissection, the other to take the risk against medical advice and not remove any more lymph nodes, the third to enter the trial. If I entered the trial and was chosen not to have the axilla dissected I would have the advantage of being closely monitored. This would be the same if I had the axilla dissected. I had to feel comfortable with someone else (a computer!) making the choice for me.

After careful consideration I decided to participate. I signed up, my details were entered into the computer and within seconds the decision was made to have the axilla dissected. It was only then I knew I had made the right decision. I had my surgery and found I had no other lymph node involvement. Of the 20 removed there was only one lymph node involved. With hindsight I would not have needed to have further surgery.

I believe this justifies my participation in the study. Peter Mac is hoping to recruit 15 Australian participants for this trial. I was only the second. I hope that very soon the Australian Standard for every woman with early stage breast cancer is to undergo sentinel node biopsy.

 

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